Inotropic'A'ring substituted sulmazole and isomazole analogs

P Barraclough, JW Black, D Cambridge…

Index: Barraclough; Black; Cambridge; Collard; Firmin; Gerskowitch; Glen; Giles; Hill; Hull; Iyer; King; Kneen; Lindon; Nobbs; Randall; Shah; Smith; Vine; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2231 - 2239

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Citation Number: 28

Abstract

CI OMe 54 55 shown in Scheme 11. 2, 3-Diamino-5-methoxypyridine (23) proved to be the most difficult isomer to obtain. After many unsuccessful attempts to prepare 23, which involved putative nitrations of numerous aminomethoxy-and halomethoxypyridines, the four- step process outlined in Scheme I11 proved to be a workable route. Direct reaction of dibromide 4817 with ammonia gave under vigorous conditions diamine 52, while under ...