Synthesis and 2D QSAR of O-sulphonated β-aminols derivatives as novel antifungal and antibacterial agents

S Sharma, AK Pandey, PK Shukla…

Index: Saxena, Anil K.; Sharma, Sugandha; Pandey, Atindra K.; Shukla, Praveen K. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6476 - 6481

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Citation Number: 3

Abstract

Synthesis of a series of β-aminol derivatives using regioselective opening reaction catalyzed by SiO2 (60–120mesh) and O-sulphonation in THF–KOH system, comprising tert- butoxycarbonyl at secondary nitrogen and evaluate for various stains of bacteria and fungi. SAR study of synthesized compound using backward regression analysis.