Discovery of 2-methoxy-3-phenylsulfonamino-5-(quinazolin-6-yl or quinolin-6-yl) benzamides as novel PI3K inhibitors and anticancer agents by bioisostere

T Shao, J Wang, JG Chen, XM Wang, H Li, YP Li…

Index: Shao, Teng; Wang, Juan; Chen, Jian-Gang; Wang, Xiao-Meng; Li, Huan; Li, Yi-Ping; Li, Yan; Yang, Guang-De; Mei, Qi-Bing; Zhang, San-Qi European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 96 - 105

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Citation Number: 16

Abstract

Abstract 2-Substituted-3-sulfonamino-5-(quinazolin-6-yl or quinolin-6-yl) benzamides have been proposed as novel structures of PI3K inhibitors and anticancer agents based on bioisostere. In the present study, 2-substituted-3-sulfonamino-5-(4-morpholinoquinazolin-6- yl) benzamides and 2-methoxy-3-sulfonamino-5-(4-morpholinoquinolin-6-yl) benzamides were synthesized. Their antiproliferative activities in vitro were evaluated via MTT assay ...