SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P 4) receptor

…, M Guerrero, J Zhao, S Velaparthi, MT Schaeffer…

Index: Urbano, Mariangela; Guerrero, Miguel; Zhao, Jian; Velaparthi, Subash; Schaeffer, Marie-Therese; Brown, Steven; Rosen, Hugh; Roberts, Edward Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5470 - 5474

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Citation Number: 14

Abstract

Recent evidence suggests an innovative application of chemical modulators targeting the S1P4 receptor as novel mechanism-based drugs for the treatment of influenza virus infection. Modulation of the S1P4 receptor may also represent an alternative therapeutic approach for clinical conditions where reactive thrombocytosis is an undesired effect or increased megakaryopoiesis is required. With the exception of our recent research ...