Substituted 5, 6-dihydrofuro [3, 2-f]-1, 2-benzisoxazole-6-carboxylic acids: high-ceiling diuretics with uricosuric activity

JJ Plattner, AKL Fung, JA Parks, RJ Pariza…

Index: Plattner; Fung; Parks; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1016 - 1026

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Citation Number: 35

Abstract

14, R= Et 15, R= HX= H, Me, OMe, halo; R= dkyl, aryl to obtain the title compounds by two separate synthetic routes, the application of which depends upon the nature and position of the substituents. Reaction Scheme I was particularly useful for preparing compounds containing a chloro substituent at position 8 and an aryl ring (without an ortho halogen) at position 3. In this process a suitably substituted benzoyl chloride derivative 7 was allowed ...