Tetrahedron letters

Asymmetric hydrogenation of 3-alkylidene-2-piperidones using Noyori's catalyst. Effect of N-substituents on the enantioselectivity

…, D Zhao, DL Hughes, JM McNamara, EJJ Grabowski…

Index: Chung, John Y. L.; Zhao, Dalian; Hughes, David L.; McNamara, James M.; Grabowski, Edward J. J.; Reider, Paul J. Tetrahedron Letters, 1995 , vol. 36, # 41 p. 7379 - 7382

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Citation Number: 23

Abstract

The enantioselectivity in the asymmetric hydrogenation of 3-alkylidene-2-piperidones catalyzed by BINAP-Ru (II) complex was found to be significantly effected by the internal substituents on the lactam nitrogen, affording the corresponding 3-alkyl-2-piperidones in 52– 92% ee.