Liebigs Annalen der Chemie

Preparative Bioorganic Chemistry, XI Preparation of the Enantiomers of Paraconic Acid Employing Lipase??Mediated Asymmetric Hydrolysis of Prochiral Diacetates as …

K Mori, N Chiba

Index: Mori, Kenji; Chiba, Naoki Liebigs Annalen der Chemie, 1989 , p. 957 - 962

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Abstract

Abstract (S)-(-)-Paraconic acid (1) was prepared from 2-(acetoxymethyl)-3-phenylpropyl acetate (4) by its asymmetric hydrolysis with pig pancreatic lipase as the key step. Similarly,(R)-(+)-1 was prepared from 2-(acetoxymethyl)-4-pentenyl acetate (2) by its asymmetric hydrolysis with lipase MY.