Three-dimensional common-feature hypotheses for octopamine agonist 2-(arylimino) imidazolidines

…, M Morimoto, E Kuwano, E Taniguchi, M Eto

Index: Hirashima, Akinori; Morimoto, Masako; Kuwano, Eiichi; Taniguchi, Eiji; Eto, Morifusa Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 1 p. 117 - 123

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Citation Number: 19

Abstract

Three-dimensional pharmacophore hypotheses were built from a set of 10 octopamine (OA) agonist 2-(Arylimino) imidazolidines (AIIs), 2-(Arylimino) thiazolidines (AITs) and 2- (Arylimino) oxazolidines (AIOs). Among the 10 common-featured models generated by program Catalyst/HipHop, a hypothesis including a ring aromatic (RA), a positive ionizable (PI) and three hydrophobic aliphatic (HpAl) features was considered to be important in ...