Chemical and pharmaceutical bulletin

The First Example of. ALPHA.-Thiomagnesiums Generated from Dithioacetal Monoxides with Grignard Reagent; Their Properties and Some Synthetic Applications.

T Satoh, K Akita

Index: Satoh, Tsuyoshi; Akita, Kiyoshi Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 2 p. 181 - 186

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Citation Number: 13

Abstract

Dithioacetal monoxides were synthesized from aldehydes and cyclohexanone, and reaction of the dithioacetal monoxides with Grignard reagents was investigated. The dithioacetal monoxide synthesized from alkylaldehyde and 4-chlorobenzenethiol reacted with i-PrMgCl to afford the desired α-thiomagnesium in high yield. The generated α-thiomagnesium was found to be stable at room temperature and to be useful in organic synthesis. In contrast to ...