Abstract Chain-extension of L-glutamate aldehyde 3 by means of the Wittig− Horner reaction furnished the desired C 7 dicarboxylic acid derivative, which in turn, after CC double bond hydrogenation and protecting group manipulation, afforded the 2, 6-diaminopimelic acid derivatives (S, R)-9 and (S, S)-9, both with the desired orthogonal protecting group pattern. Synthesis of the muramic acid derivative 15 and attachment of an L-alanine residue ...
[Luesch, Hendrik; Hoffmann, Dietmar; Hevel, Joan M.; Becker, Julia E.; Golakoti, Trimurtulu; Moore, Richard E. Journal of Organic Chemistry, 2003 , vol. 68, # 1 p. 83 - 91]
