Synthesis and anti-breast cancer activities of substituted quinolines

…, TA Nguyen, SK Battina, S Rana, DJ Takemoto…

Index: Shi, Aibin; Nguyen, Thu A.; Battina, Srinivas K.; Rana, Sandeep; Takemoto, Dolores J.; Chiang, Peter K.; Hua, Duy H. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3364 - 3368

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Citation Number: 69

Abstract

Promising anti-breast cancer agents derived from substituted quinolines were discovered. The quinolines were readily synthesized in a large scale from a sequence of reactions starting from 4-acetamidoanisole. The Michael addition product was isolated as the reaction intermediate in the ring closing reaction of 4-amino-5-nitro-2-(3-trifluoromethylphenyloxy) anisole with methyl vinyl ketone leading to 6-methoxy-4-methyl-8-nitro-5-(3- ...