Synthesis and Biological Evaluation of [1, 2, 4] Triazolo [3, 4??a] phthalazine and Tetrazolo [5, 1??a] phthalazine Derivatives Bearing Substituted Benzylpiperazine …

Y Wu, LP Sun, LX Ma, J Che, MX Song…

Index: Wu, Yan; Sun, Liang-Peng; Ma, Long-Xu; Che, Jian; Song, Ming-Xia; Cui, Xun; Piao, Hu-Ri Chemical Biology and Drug Design, 2013 , vol. 81, # 5 p. 591 - 599

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Citation Number: 5

Abstract

Two series of [1, 2, 4] triazolo [3, 4-a] phthalazine and tetrazolo [5, 1-a] phthalazine derivatives bearing substituted benzylpiperazine moieties have been synthesized and evaluated for their positive inotropic activity by measuring left atrium stroke volume on isolated rabbit heart preparations. The majority of the derivatives exhibited better in vitro activity than the existing drug, milrinone, and 6-((4-(4-methoxyphenyl) piperazin-1-yl) ...