Vanilloids are natural irritants possessing a 4-hydroxy-3-methoxybenzyl group as essential moiety to express their bioactivity 1-3 View all references. Besides their irritancy, vanilloids have attracted considerable attention for the last decade due to their strong analgesic properties 4-5 View all references. Capsaicin and its ultrapotent analog, resiniferatoxin (RTX), are the best-known natural vanilloids. In the course of our research aimed at the development of new vanilloids as ...
