CRF Ligands via suzuki and negishi couplings of 3-pyridyl boronic acids or halides with 2-benzyloxy-4-chloro-3-nitropyridine

AG Arvanitis, CR Arnold, LW Fitzgerald…

Index: Arvanitis, Argyrios G; Arnold, Charles R; Fitzgerald, Lawrence W; Frietze, William E; Olson, Richard E; Gilligan, Paul J; Robertson, David W Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 289 - 291

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Citation Number: 12

Abstract

A series of imidazo [4, 5-b] pyridines with a 7-(3-pyridyl) substituent is described as high affinity CRF receptor ligands. Individual analogues were synthesized from key intermediates obtained via palladium-catalyzed coupling of 3-pyridyl zinc or boronic acid organometallic intermediates with 2-benzyloxy-4-chloro-3-nitropyridine 12.