Optically active α-heterosubstituted aldehydes are versatile building blocks for the synthesis of chiral molecules that bear heteroatom functionalities. Recent advances in the synthesis of these molecules have been focused on the development of direct organocatalytic procedures [1] that avoid metal catalysts and reagents. Organocatalyzed additions of simple carbonyl compounds to diazocarboxylates and nitrosobenzene allow the incorporation of ...
![(2S)-2-{Diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine Structure](https://image.chemsrc.com/caspic/289/848821-58-9.png)
![(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol Structure](https://image.chemsrc.com/caspic/441/848821-76-1.png)
