Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents

…, YR Prasad, L Gharat, A Thomas, P Ravikumar…

Index: Lakshminarayana; Rajendra Prasad; Gharat, Laxmikant; Thomas, Abraham; Ravikumar; Narayanan, Shridhar; Srinivasan; Gopalan, Balasubramanian European Journal of Medicinal Chemistry, 2009 , vol. 44, # 8 p. 3147 - 3157

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Citation Number: 24

Abstract

A series of novel isochroman mono-carboxylic acid derivatives were synthesized, characterized and evaluated for their ability to inhibit protein tyrosine phosphatase 1B (PTP1B) in vitro in order to use them as potential anti-diabetic agents. Analysis of structure– activity relationships led to the identification of potent compound 4n which inhibited PTP1B with IC50 value of 51.63±0.91 nM. In general, high potency was associated with a ...