Incorporation of piperazino functionality into 1, 3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with …

SX Huang, HY Li, JY Liu, C Morisseau…

Index: Journal of Medicinal Chemistry, , vol. 53, # 23 p. 8376 - 8386

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Citation Number: 15

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. Scheme 1 outlines the syntheses of the 1-adamantan-1-yl 3-substituted ureas having a phenyl ring between the urea group and the piperazino group in a para-, meta-, or ortho-substitution pattern, separately. ...