Synthesis of 3-fluoroimidazo [1, 2-a] pyrimidines and 5-fluoroimidazo [2, 1-b][1, 3] thiazoles via heterocyclization of (N-heteroarylimino) trifluoropyruvates

YV Rassukana, YY Khomutnyk, PP Onys'ko…

Index: Rassukana; Khomutnyk; Onys'Ko; Sinitsa; Gakh Journal of Fluorine Chemistry, 2010 , vol. 131, # 10 p. 1044 - 1048

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Citation Number: 11

Abstract

Synthesis of 3-fluoroimidazo [1, 2-a] pyrimidines and 5-fluoroimidazo [2, 1-b][1, 3] thiazoles was accomplished via triethyl phosphite-induced heterocyclization of the corresponding N- (heteroarylimino) trifluoropyruvates. This method provides a convenient approach to synthesize ring-fluorinated fused imidazoles of biological relevance.