Controlled Axial Coordination: Solid??Phase Synthesis and Purification of Metallo??Radiopharmaceuticals

…, PJ Barnard, SR Bayly, JR Dilworth…

Index: Betts, Helen M.; Barnard, Peter J.; Bayly, Simon R.; Dilworth, Jonathan R.; Gee, Antony D.; Holland, Jason P. Angewandte Chemie - International Edition, 2008 , vol. 47, # 44 p. 8416 - 8419

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Citation Number: 22

Abstract

Solid-supported reagents show great potential for improving the synthesis of radiodiagnostic agents, in terms of radiochemical yield and purity, as well as convenience and safety. The preparation of the positron emission tomography (PET) imaging agent [18F]-2-fluoro-2- deoxy-d-glucose has recently been demonstrated using a solid-bound substrate which is selectively cleaved from the solid support upon reaction with [18F]-fluoride ions.[1] Whilst ...