Diprotodecarboxylation Reactions of 3, 4-Dialkoxythiophene-2, 5-dicarboxylic Acids Mediated by Ag2CO3 and Microwaves

PA Cisneros-Pérez, D Martínez-Otero…

Index: Cisneros-Perez, Pablo A.; Martinez-Otero, Diego; Cuevas-Yanez, Erick; Uribe-Frontana, Bernardo A. Synthetic Communications, 2014 , vol. 44, # 2 p. 222 - 230

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Abstract

An efficient and rapid method is reported to obtain 3,4-dialkoxythiophenes from 3,4-dialkoxythiophene-2,5-dicarboxylic acids through a diprotodecarboxylation reaction with Ag 2 CO 3 /AcOH as a catalytic system and microwave heating in dimethylsulfoxide (DMSO) as solvent. This methodology lets us obtain for the first time good performance with thiophenes bearing strong electron-donating groups such as alkoxides. This methodology eliminates ...