Novel Carboline Derivatives as Potent Antifungal Lead Compounds: Design, Synthesis, and Biological Evaluation

S Wang, Y Wang, W Liu, N Liu, Y Zhang…

Index: Wang, Shengzheng; Wang, Yan; Liu, Wei; Liu, Na; Zhang, Yongqiang; Dong, Guoqiang; Liu, Yang; Li, Zhengang; He, Xiaomeng; Miao, Zhenyuan; Yao, Jianzhong; Li, Jian; Zhang, Wannian; Sheng, Chunquan ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 5 p. 506 - 511

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Citation Number: 11

Abstract

A series of novel antifungal carboline derivatives was designed and synthesized, which showed broad-spectrum antifungal activity. Particularly, compound C38 showed comparable in vitro antifungal activity to fluconazole without toxicity to human embryonic lung cells. It also exhibited good fungicidal activity against both fluconazole-sensitive and-resistant Candida albicans cells and had potent inhibition activity against Candida albicans biofilm ...