Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) …

…, A Abate, C Bigogno, R Boggio, G Carenzi…

Index: Varasi, Mario; Thaler, Florian; Abate, Agnese; Bigogno, Chiara; Boggio, Roberto; Carenzi, Giacomo; Cataudella, Tiziana; Dal Zuffo, Roberto; Fulco, Maria Carmela; Rozio, Marco Giulio; Mai, Antonello; Dondio, Giulio; Minucci, Saverio; Mercurio, Ciro Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 3051 - 3064

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Citation Number: 24

Abstract

New spiro [chromane-2, 4′-piperidine] and spiro [benzofuran-2, 4′-piperidine] hydroxamic acid derivatives as HDAC inhibitors have been identified by combining privileged structures with a hydroxamic acid moiety as zinc binding group. The compounds were evaluated for ...