Leukotriene biosynthesis inhibitors have potential as new therapeutic agents for asthma and inflammatory diseases. A series of novel substituted 2-cyanoquinolines have been synthesized and the structure activity relationships were evaluated with respect to their ability to inhibit the formation of leukotrienes via the 5-lipoxygenase enzyme.[1S, 5R]-2- Cyano-4-(3-furyl)-7-3-fluoro-5-[3-(3α-hydroxy-6, 8-dioxabicyclo [3.2. 1]-octanyl)] ...
