Tetrahedron letters

A new approach to the synthesis of lysophospholipids: preparation of lysophosphatidic acid and lysophosphatidylcholine from p-nitrophenyl glycerate

R Rosseto, N Bibak, J Hajdu

Index: Rosseto, Renato; Bibak, Niloufar; Hajdu, Joseph Tetrahedron Letters, 2004 , vol. 45, # 39 p. 7371 - 7373

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Citation Number: 11

Abstract

A new stereospecific synthesis of lysophosphatidic acid and lysophosphatidylcholine is reported. The sequence relies on p-nitrophenyl-d-glycerate as a chiral synthon, including chemoselective reduction of the active ester function without affecting other carboxylic ester groups present in the molecule.