e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
The Journal of organic chemistry
Simple reaction conditions for the formation of ketonitrones from ketones and hydroxylamines
JY Pfeiffer, AM Beauchemin
Index: Bourgeois, Joffre; Dion, Isabelle; Cebrowski, Pamela H.; Loiseau, Francis; Bedard, Anne-Catherine; Beauchemin, Andre M. Journal of the American Chemical Society, 2009 , vol. 131, p. 874 - 875
The condensation of ketones and hydroxylamines to form ketonitrones was reinvestigated by using thermal conditions previously found to minimize hydroxylamine decomposition (t- BuOH, 110° C). This simple approach allows the formation of exocyclic, acyclic, and α, β- unsaturated ketonitrones with benzylic, linear, and branched nitrogen substituents in modest to excellent isolated yields.
