Journal of Medicinal chemistry

Preparation and hypoglycemic activity of some 3, 5-disubstituted hydantoins

JG Lombardino, CF Gerber

Index: Lombardino,J.G.; Gerber,C.F. J. Med. Chem., 1964 , vol. 7, p. 97 - 101

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Citation Number: 6

Abstract

Yields were usually near quantitative and first crops analytically pure. Table I1 summarizes the data on these 3-substituted 5-alkylhydantoins. Some compounds of type I were optically active (footnotes to Table 11) suggesting that the series of reactions from optically active amino ester to the hydantoins I probably had little effect on the asymmetric carbon atom.