An efficient synthesis of isotope??labeled PD0331179 and its labeled metabolite

Y Zhang

Index: Zhang, Yinsheng Journal of Labelled Compounds and Radiopharmaceuticals, 2012 , vol. 55, # 11 p. 419 - 422

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Abstract

4-[1-Methyl-2, 4-dioxo-6-(3-phenyl-prop-1-ynyl)-1, 4-dihydro-2H-quinazolin-3-ylmethyl]- benzoic acid, PD0331179, was under investigation as a matrix metalloproteinase-13 inhibitor. 14C-labeled and 2H-labeled PD0331179 and its 2H-labeled metabolite (PD0335699) were required to support its preclinical and clinical studies.[14C] 3-phenyl-1- trimethyl/triphenylsilyl-propyne was efficiently prepared starting with [14C] benzoic acid ...