Supramolecular effects on the antifungal activity of cyclodextrin/di-n-decyldimethylammonium chloride mixtures

…, A Dewilde, JM Aubry, V Nardello-Rataj

Index: Leclercq, Loic; Lubart, Quentin; Dewilde, Anny; Aubry, Jean-Marie; Nardello-Rataj, Veronique European Journal of Pharmaceutical Sciences, 2012 , vol. 46, # 5 p. 336 - 345

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Citation Number: 14

Abstract

Candidiasis infections are growing problem worldwide especially for the immunocompromised individuals. Di-n-decyldimethylammonium chloride is one of the most common antifungal agents used to clean medical devices. The current study examines the antifungal mechanism of di-n-decyldimethylammonium cation and its cyclodextrin inclusion complexes. Depending on the type of cyclodextrin (α-, β-or γ-CD), inclusion complexes ...