Function of the alkyl side chains of Δlac-acetogenins in the inhibitory effect on mitochondrial complex I (NADH-ubiquinone oxidoreductase)

…, M Murai, M Senoh, T Nishioka, H Miyoshi

Index: Ichimaru, Naoya; Abe, Masato; Murai, Masatoshi; Senoh, Mai; Nishioka, Takaaki; Miyoshi, Hideto Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3555 - 3558

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Citation Number: 11

Abstract

We synthesized a series of Δlac-acetogenins in which the two alkyl side chains were systematically modified, and examined their inhibitory effect on bovine heart mitochondrial complex I (NADH-ubiquinone oxidoreductase). The results revealed that the physicochemical properties of the side chains, such as the balance of hydrophobicity and the width (or bulkiness) of the chains, are important structural factors for a potent inhibitory ...