Oxidant-Free Conversion of Cyclic Amines to Lactams and H2 Using Water As the Oxygen Atom Source

JR Khusnutdinova, Y Ben-David…

Index: Khusnutdinova, Julia R.; Ben-David, Yehoshoa; Milstein, David Journal of the American Chemical Society, 2014 , vol. 136, # 8 p. 2998 - 3001

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Citation Number: 36

Abstract

Direct conversion of cyclic amines to lactams utilizing water as the only reagent is catalyzed by pincer complex 2. In contrast to previously known methods of amine-to-amide conversion, this reaction occurs in the absence of oxidants and is accompanied by liberation of H2, with water serving as a source of oxygen atom. Formation of a cyclic hemiaminal intermediate plays a key role in enabling such reactivity. This represents an unprecedented, ...