New Convenient Approach for the Synthesis of Benzyl 2H-Chromenones and their α-Amylase Inhibitory, ABTS.+ Scavenging Activities

…, G Saidachary, D Anand Kumar, Z Ali…

Index: Kumar, Jaladi Ashok; Tiwari, Ashok Kumar; Saidachary, Gannerla; Kumar, Domati Anand; Ali, Zehra; Sridhar, Balasubramanian; Raju, Bhimapaka China Medicinal Chemistry, 2013 , vol. 9, # 6 p. 806 - 811

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Abstract

Series of new benzyl 2H-chromenones 6a-n was synthesized by Pechmann condensation of substituted benzyl resorcinols 2a-c and 3a with various β-ketoesters such as ethyl 3- oxobutanoate, ethyl 3-oxo-3-phenylpropanoate, ethyl 4-chloro-3-oxobutanoate, ethyl 4, 4, 4- trifluoro-3-oxobutanoate and ethyl 2-chloro-3-oxobutanoate 5a-e in very good yields. Synthesized compounds 6a-n were screened for their α-amylase inhibitory, and ABTS.+ ...