The first large-scale synthesis of MK-4305: a dual orexin receptor antagonist for the treatment of sleep disorder

CA Baxter, E Cleator, KMJ Brands…

Index: Organic Process Research and Development, , vol. 15, # 2 p. 367 - 375

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Citation Number: 39

Abstract

... Organic Process Research & Development. ... figure Scheme 2. Proposed process research route to 1. The main objective was to remove unnecessary protecting group manipulations from ... to obtain the scalemic salt 16, control of the salt form was required in the resolution process. ...