Synthesis and anti-tuberculosis activity of a new series of 2, 4-disubstituted quinolines have been reported. The most promising compounds have been found to exhibit 99% inhibition at 6.25 µg/mL against drug-sensitive M. tuberculosis H37Rv strain and> 90% inhibition at 12.5 µg/mL against isoniazid resistant TB strain. Keywords: Tuberculosis, ring-substituted quinolines, drug-sensitive TB, drug-resistant TB, multi-drug resistant TB, extreme drug- ...
