Advanced Synthesis and Catalysis

Chemoenzymatic synthesis of trinitrobenzyl halides as an alternative approach to hexanitrostilbene

IZ Munir, S Hu, JS Dordick

Index: Munir, Inmar Z.; Hu, Shanghui; Dordick, Jonathan S. Advanced Synthesis and Catalysis, 2002 , vol. 344, # 10 p. 1097 - 1102

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Citation Number: 7

Abstract

Abstract: The selective oxidation and halogenation of nitroaromatics is a difficult task both chemically and enzymatically. We have discovered that vanadium chloro-and bromoperoxidases from Curvularia inaequalis and Corralina officinalis, respectively, are capable of catalyzing the hydroxylation, halogenation, and demethylation of 2, 4, 6- trinitrotoluene (TNT) under alkaline conditions. At pH8, the conversions for hydroxylation ...