Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Schmidtchen's methodology is used successfully for the synthesis of the chiral disubstituted bicyclic guanidinium salt 2. The two therefore required primary amine compounds 6 and 9 are obtained from L-methionine and L-glutamic acid, respectively. ... The chiral regioselectively ...