Advanced Synthesis & Catalysis

Highly Efficient Ligands for the Palladium??Assisted Double N??Arylation of Primary Amines for One??Sep Construction of Carbazoles

Y Zhou, JG Verkade

Index: Zhou, Yibo; Verkade, John G. Advanced Synthesis and Catalysis, 2010 , vol. 352, # 4 p. 616 - 620

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Citation Number: 30

Abstract

Abstract A highly efficient one-pot synthesis of carbazoles via palladium-catalyzed double N- arylation of primary amines with 2, 2′-dihalobiphenyls is described using a catalyst system comprised of tris (dibenzylideneacetone) dipalladium (0)(Pd 2 dba 3) and the proazaphosphatrane P (i-BuNCH 2 CH 2) 3 N (8) or its derivative (t-Bu) 2 P [DOUBLE BOND] N [BOND] P (i-BuNCH 2 CH 2) 3 N (9a) as the ligand. The process is effective for ...