Journal of fluorine chemistry

Elemental fluorine. Part 9: Catalysis of the direct fluorination of 2-substituted carbonyl compounds2Dedicated to Professor Klaus Burger on the occasion of his 60th …

RD Chambers, J Hutchinson

Index: Chambers, Richard D.; Hutchinson, John Journal of Fluorine Chemistry, 1998 , vol. 92, # 1 p. 45 - 52

Full Text: HTML

Citation Number: 57

Abstract

Catalysis of the reaction between fluorine and a range of 2-substituted carbonyl compounds has been investigated. Most notably, the preparation of diethyl-2-fluoromalonate has been achieved in high yield by fluorination of diethylmalonate in the presence of hydrated copper nitrate. Reactions between fluorine and carbanions derived from 2-substituted carbonyl compounds, including phosphonates, sulphones and nitriles, are also discussed.