Synthesis of neamine-based pseudodisaccharides as potential vestibulotoxic agents to treat vertigo in Ménière's disease

…, DF Kawano, MR de Carvalho, JAA de Oliveira…

Index: Pinsetta, Flavio Roberto; Kawano, Daniel Fabio; De Carvalho, Marcelo Rodrigues; De Oliveira, Jose Antonio A.; Corrado, Alexandre P.; Hyppolito, Miguel Angelo; Carvalho, Ivone Carbohydrate Research, 2013 , vol. 373, p. 97 - 102

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Citation Number: 5

Abstract

Ménière's disease (MD) is a progressive disease of the inner ear characterized by recurring attacks of disabling vertigo, hearing loss and tinnitus. Patients who do not respond to vestibular sedatives or steroids may require an intratympanic application of aminoglycoside antibiotics, which destroys the vestibular function of the affected ear in order to avoid the debilitating vertigo attacks. Although effective, this procedure causes hearing loss in ...