e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis of nevirapine and its major metabolite

…, J Vitous, S Campbell, J Adams

Index: Grozinger; Fuchs; Hargrave; Mauldin; Vitous; Campbell; Adams Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 1 p. 259 - 263

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Citation Number: 29

Abstract

Abstract Several synthetic methods were developed during the process optimization for the large scale synthesis of nevirapine (1), a non-nucleoside inhibitor of HIV-1 Reverse Transcriptase. The synthesis of its putative major metabolite 11-cyclopropyl-5, 11-dihydro- ...

nevirapine Structure

~30%

11-Cyclopropyl-5,11-dihydro-4-(hydroxyMethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one Structure

11-Cyclopropyl-...

2-Chloronicotinyl chloride Structure

2-Chloronicotin...

2,6-dichloro-4-methylpyridin-3-amine Structure

2,6-dichloro-4-...

~87%

2-chloro-N-(2,6-dichloro-4-methylpyridin-3-yl)pyridine-3-carboxamide Structure

2-chloro-N-(2,6...

2,6-dichloro-4-methylnicotinamide Structure

2,6-dichloro-4-...

~89%

2,6-dichloro-4-methylpyridin-3-amine Structure

2,6-dichloro-4-...

Synthesis of five nevirapine metabolites

[Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239]

Synthesis of five nevirapine metabolites

[Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239]

Synthesis of five nevirapine metabolites

[Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239]

Synthesis of five nevirapine metabolites

[Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239]

Synthesis of five nevirapine metabolites

[Grozinger, Karl G.; Byrne, Denis P.; Nummy, Laurence J.; Ridges, Michael D.; Salvagno, Annette Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 2 p. 229 - 239]