e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
5-deazafolate analogues with a rotationally restricted glutamate or ornithine side chain: synthesis and binding interaction with folylpolyglutamate synthetase
A Rosowsky, RA Forsch, A Null…
Index: Rosowsky, Andre; Forsch, Ronald A.; Null, Allison; Moran, Richard G. Journal of Medicinal Chemistry, 1999 , vol. 42, # 18 p. 3510 - 3519
Rotationally restricted analogues of 5-deazapteroyl-l-glutamate and (6 R, 6 S)-5-deaza-5, 6, 7, 8-tetrahydropteroyl-l-glutamate with a one-carbon bridge between the amide nitrogen and the 6'-position of the p-aminobenzoyl moiety were synthesized and tested as substrates for folylpolyglutamate synthetase (FPGS), a key enzyme in folate metabolism and an important determinant of the therapeutic potency and selectivity of classical antifolates. The ...
