New Scalable Asymmetric Aminomethylation Reaction for the Synthesis of β2??Amino Acids

R Moumné, B Denise, K Guitot, H Rudler…

Index: Moumne, Roba; Denise, Bernard; Guitot, Karine; Rudler, Henri; Lavielle, Solange; Karoyan, Philippe European Journal of Organic Chemistry, 2007 , # 12 p. 1912 - 1920

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Citation Number: 6

Abstract

Abstract β-Amino acids are useful tools in the design of peptidomimetics, and the development of new methods for their syntheses, particularly the synthesis of β 2-amino acids, remains an important challenge. Here we report a new scalable route based on the aminomethylation of silyl ketene N, O-acetals by Mannich-type iminium electrophiles.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)