Transition Metal–Free Sodium Borohydride Promoted Controlled Hydration of Nitriles to Amides

PK Verma, N Kumar, U Sharma, M Bala…

Index: Verma, Praveen Kumar; Kumar, Neeraj; Sharma, Upendra; Bala, Manju; Kumar, Vishal; Singh, Bikram Synthetic Communications, 2013 , vol. 43, # 21 p. 2867 - 2875

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Citation Number: 3

Abstract

A transition metal–free process, promoted by sodium borohydride, has been developed for convenient and selective hydration of nitriles to corresponding amides. The present process converts the aromatic, aliphatic, and heteroaromatic nitriles with wide functional group tolerance. The regioselective hydration of one nitrile moiety in the presence of an other nitrile group makes high impact in the present protocol. ... [Supplementary materials are available for this article. Go to the ...