On the basis of our previous findings, a series of 5-substituted 2-iminohydantoins has been synthesized and tested for anticonvulsant activity to better understand the SAR of 2- iminohydantoins. Among the compounds tested,(SI-(+)-l-carbobenzoxy-2-iminohydantoin analogs with ethyl (6)-, n-propyl (7a)-, isopropyl (8)-, allyl (9)-, and sec-butyl (Wsubstituted groups at the C5 of the iminohydantoin ring provided the best activities against the MES ...
