Tetrahedron Letters

Selective para metalation of unprotected 3-methoxy and 3, 5-dimethoxy benzoic acids with n-butyl lithium–potassium tert-butoxide (LIC–KOR): synthesis of 3, 5- …

S Sinha, B Mandal, S Chandrasekaran

Index: Sinha, Surajit; Mandal, Bhubaneswar; Chandrasekaran, Srinivasan Tetrahedron Letters, 2000 , vol. 41, # 17 p. 3157 - 3160

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Citation Number: 12

Abstract

The potassium salt of 3-methoxy and 3, 5-dimethoxy benzoic acids undergoes deprotonation at the position para to the carboxylate group selectively when treated with LIC– KOR in THF at− 78° C and it has been extended to the synthesis of 3, 5-dimethoxy-4-methyl benzoic acid.