The Journal of Organic Chemistry

Regioselectivity in intramolecular nucleophilic aromatic substitution. Synthesis of the potent anti HIV-I 8-halo TIBO analogs

KA Parker, CA Coburn

Index: Parker, Kathlyn A.; Coburn, Craig A. Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 97 - 100

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Citation Number: 36

Abstract

In a recent communication,'we described the synthesis of TIBO R82150 (la), an inhibitor of HIV-1 replication: by a four-step sequence. A key transformation in that four-step preparation was the conversion of intermediate 2a to bicyclic 3a by intramolecular nucleophilic aromatic substit~ tion.~