Convenient general asymmetric synthesis of roche ester derivatives through catalytic asymmetric hydrogenation: steric and electronic effects of ligands

…, JP Genêt, V Ratovelomanana??Vidal

Index: Pautigny, Cyrielle; Jeulin, Severine; Ayad, Tahar; Zhang, Zhaoguo; Genet, Jean-Pierre; Ratovelomanana-Vidal, Virginie Advanced Synthesis and Catalysis, 2008 , vol. 350, # 16 p. 2525 - 2532

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Citation Number: 32

Abstract

Abstract An efficient and concise asymmetric hydrogenation of acrylate esters promoted by the cationic ruthenium monohydride complex [Ru (H)(η 6-cot) SYNPHOS]+ BF 4− is reported. A full investigation of the effects of catalyst precursors, solvents, temperature, hydrogen pressure, substrates as well as steric and electronic properties of ligands was carried out. The corresponding valuable Roche ester derivatives were obtained in good to ...