Methyl 3-cyclopropyl-3-oxopropanoate in the synthesis of heterocycles having a cyclopropyl substituent

NT Pokhodylo, VS Matiichuk, ND Obushak

Index: Pokhodylo; Matiichuk; Obushak Russian Journal of Organic Chemistry, 2010 , vol. 46, # 6 p. 894 - 897

Full Text: HTML

Citation Number: 1

Abstract

Abstract Reactions of methyl 3-cyclopropyl-3-oxopropanoate with chloroacetone and ammonia, benzaldehyde and ammonia, and benzoquinone gave, respectively, methyl 2- cyclopropyl-5-methyl-1 H-pyrrole-3-carboxylate, dimethyl 2, 6-dicyclopropyl-4-phenyl-1, 4- dihydropyridine-3, 5-dicarboxylate, and methyl 2-cyclopropyl-5-hydroxy-1-benzofuran-3- carboxylate. Cyclization of methyl 3-cyclopropyl-3-oxopropanoate with ethyl chloro ( ...