Synthesis of NO–NSAID dendritic prodrugs via Passerini reaction: new approach to the design of dendrimer-drug conjugates

Z Du, Y Lu, X Dai, D Zhang-Negrerie…

Index: Du, Zuyin; Yanhui, Lu; Dai, Xuedong; Zhang-Negrerie, Daisy; Gao, Qingzhi Journal of Chemical Research, 2013 , vol. 37, # 3 p. 181 - 185

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Citation Number: 4

Abstract

We report the synthesis of a novel class of dendritic prodrugs via Passerini reaction in one pot. Such dendrimers feature a simultaneous attachment of a conventional non-steroidal anti- inflammatory drug (NSAID)(such as ibuprofen and aspirin) and a nitric oxide (NO)-releasing moiety (such as an organic nitrate) onto their surface, and are therefore regarded as new drug delivery systems for NO-releasing NSAIDs (NO–NSAIDs).