In vitro mutagenicity of anti-inflammatory parsalmide analogues PA7, PA10, and PA31 triggered by biotransformation into hydroxy derivatives

HS Cardoso, B Bicalho, P Genari, V Santagada…

Index: Cardoso; Bicalho; Genari; Santagada; Caliendo; Perissutti; Donato; De Nucci European Journal of Medicinal Chemistry, 2006 , vol. 41, # 3 p. 408 - 416

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Citation Number: 3

Abstract

In this study, the mutagenicity of the anti-inflammatory parsalmide [5-amino-N-butyl-2-(2- propynyloxy)-benzamide] analogues PA7 [5-amino-N-butyl-2-cyclohexyloxy-benzamide], PA10 [5-amino-N-butyl-2-phenoxy-benzamide] and PA31 [5-amino-N-butyl-2-(p-tolyloxy)- benzamide] was determined by an Ames Salmonella assay. The experiments were performed by preincubating the compounds in the absence and presence of a post- ...