Members of the MAP kinase family are implicated in the activation of a wide variety of transcription factors and proteins involved in the control of cytokine production. A pair of novel protein kinase homologues (p38) involved in the regulation of cytokine synthesis have been described. 1 Small molecule inhibitors of p38, such as SB 203580 1 2 and 3 (Fig. 1), can potentially lead to the treatment of osteoporosis and inflammatory disorders. ... Ureas were synthesized by the reaction of ...
